Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139974 | 0.83 | TOP2A (0.36) | TOP2ATOP2BKMT2AALDH1A1HSP90AA1 | |
| SCHEMBL20139978 | 0.81 | TOP2A (0.41) | TOP2ATOP2BKMT2AHTTALDH1A1 | |
| SCHEMBL20140072 | 0.80 | KMT2A (0.40) | TOP2ATOP2BKMT2AALDH1A1HSP90AA1 | |
| SCHEMBL20139480 | 0.77 | CHRNA7 (0.44) | TOP2ATOP2BKMT2AMEN1HTR2A | |
| SCHEMBL20140136 | 0.73 | HTR2A (0.40) | HTR2AHTR2C | |
| SCHEMBL20140153 | 0.72 | PDE2A (0.32) | TOP2ATOP2BKMT2AHTTALDH1A1 | |
| SCHEMBL16235208 | 0.70 | LMNA (0.42) | KMT2AALDH1A1GAAMEN1CYP2C19 | |
| SCHEMBL20140114 | 0.69 | TOP2A (0.37) | TOP2ATOP2BHTTALDH1A1 | |
| SCHEMBL20139430 | 0.69 | EPHX2 (0.33) | TOP2ATOP2BKMT2AHTTALDH1A1 | |
| SCHEMBL20140227 | 0.68 | SLC5A1 (0.53) | ALDH1A1HTR2ASLC5A1SLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-10-27 | — | — | US | disclosed |
| WO-2018089449-A1 | BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-17 | — | — | WO | disclosed |
| US-20160022825-A1 | NANOPARTICLES FOR MITOCHONDRIAL TRAFFICKING OF AGENTS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022825-A1 | NANOPARTICLES FOR MITOCHONDRIAL TRAFFICKING OF AGENTS | RHOT2, TFAM, MAVS | TOP2A 676/4885TOP2B 1353/4885KMT2A 4268/4885 |
| US-10815210-B2 | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators | SLC5A2, SLC5A1, SLC2A2 | TOP2A 2707/4885TOP2B 2772/4885KMT2A 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.