Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139284 | 0.87 | HTR7 (0.52) | HTR7DRD2DRD4DRD3NPY2R | |
| SCHEMBL20159024 | 0.86 | MTOR (0.64) | HTR7DRD2HTR1AMTORRPTOR | |
| SCHEMBL20159165 | 0.83 | MTOR (0.51) | HTR7DRD2HTR1AALDH1A1MTOR | |
| SCHEMBL20159036 | 0.81 | MTOR (0.58) | HTR7DRD2DRD4DRD3KDM4E | |
| SCHEMBL20139322 | 0.81 | MTOR (0.52) | HTR7NPY2RMTORRPTORMLST8 | |
| SCHEMBL20139564 | 0.81 | MTOR (0.52) | HTR7NPY2RMTORRPTORMLST8 | |
| SCHEMBL20139324 | 0.81 | MTOR (0.52) | HTR7NPY2RMTORRPTORMLST8 | |
| SCHEMBL20139286 | 0.81 | HTR7 (0.50) | HTR7DRD2DRD4DRD3HTR1A | |
| SCHEMBL20159115 | 0.81 | MTOR (0.55) | HTR7MTORRPTORMLST8 | |
| SCHEMBL20159079 | 0.80 | MTOR (0.52) | HTR7DRD2MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |