Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141002 | 0.92 | MCL1 (0.46) | LMNAHTTGAAMAPK1KMT2A | |
| SCHEMBL20141379 | 0.80 | MAPT (0.42) | LMNAGAAKMT2AKDM4EDRD4 | |
| SCHEMBL20140521 | 0.78 | ALDH1A1 (0.44) | LMNAHTTKDM4EDRD4DRD2 | |
| SCHEMBL20141860 | 0.77 | GRM1 (0.47) | DRD4DRD2DRD3MTORRPTOR | |
| SCHEMBL20140827 | 0.76 | MTOR (0.51) | LMNAHTTGAAMAPK1KMT2A | |
| SCHEMBL20139906 | 0.76 | POLB (0.47) | LMNAHTTGAAMAPK1KMT2A | |
| SCHEMBL20140960 | 0.76 | MTOR (0.46) | LMNAKDM4EDRD4DRD2DRD3 | |
| SCHEMBL5776077 | 0.75 | GFER (0.45) | LMNAKDM4EDRD4DRD2DRD3 | |
| SCHEMBL20140839 | 0.75 | POLB (0.46) | LMNAHTTKDM4EDRD4DRD2 | |
| SCHEMBL20140882 | 0.74 | PKM (0.47) | LMNAHTTGAAKDM4EGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |