Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | FGB | P02675 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140882 | 0.86 | PKM (0.47) | POLBGBA1PKMLMNAMCOLN3 | |
| SCHEMBL20139954 | 0.84 | POLB (0.45) | POLBGBA1PKMLMNAMCOLN3 | |
| SCHEMBL20140521 | 0.83 | ALDH1A1 (0.44) | POLBGBA1PKMLMNAMCOLN3 | |
| SCHEMBL20141002 | 0.83 | MCL1 (0.46) | POLBGBA1PKMLMNAMCOLN3 | |
| SCHEMBL20140839 | 0.82 | POLB (0.46) | POLBGBA1PKMLMNAALDH1A1 | |
| SCHEMBL5776077 | 0.76 | GFER (0.45) | PKMLMNAMCOLN3ALDH1A1KDM4E | |
| SCHEMBL20140827 | 0.76 | MTOR (0.51) | PKMLMNAALDH1A1KDM4EMAPT | |
| SCHEMBL20140646 | 0.76 | LMNA (0.42) | POLBGBA1LMNAMCOLN3ALDH1A1 | |
| SCHEMBL20140016 | 0.75 | HSD11B1 (0.55) | LMNAALDH1A1KDM4EL3MBTL1HSD11B1 | |
| SCHEMBL20141379 | 0.75 | MAPT (0.42) | PKMLMNAALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |