Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RBP4 | P02753 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29496346 | 0.84 | NPC1 (0.56) | TSHRSMN1; SMN2ALDH1A1NPSR1KMT2A | |
| SCHEMBL6262435 | 0.83 | DRD2 (0.54) | NPSR1HTR1ADRD2HTR2A | |
| SCHEMBL21360304 | 0.82 | BACE1 (0.54) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL20141942 | 0.80 | MTOR (0.49) | TSHRSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL1742847 | 0.80 | ADRB1 (0.51) | TSHRGAACYP2C19CYP1A2HTR1A | |
| SCHEMBL10153998 | 0.80 | ALDH1A1 (0.51) | TSHRSMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6826072 | 0.79 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL631024 | 0.76 | AKR1C3 (0.65) | TSHRALDH1A1MYCKMT2AAR | |
| SCHEMBL20140930 | 0.75 | GAA (0.38) | TSHRSMN1; SMN2GAAHTR1ADRD2 | |
| SCHEMBL418681 | 0.75 | RBP4 (0.46) | TSHRSMN1; SMN2RBP4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |