Sugi Predict

Sugi Predict / Compounds / SCHEMBL20140992

SCHEMBL20140992

SCHEMBL20140992

NC(=O)[C@@H]1CN(C(=O)O)CCN1c1ccc(F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 1/20 0.42
▸ CA12 O43570 1/20 0.41
▸ CA1 P00915 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ CA9 Q16790 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.40
▸ LMNA P02545 2/20 0.40
▸ GAA P10253 1/20 0.40
▸ MTOR P42345 1/20 0.40
▸ RPTOR Q8N122 1/20 0.40
▸ MLST8 Q9BVC4 1/20 0.40
▸ SMN1; SMN2 Q16637 4/20 0.39
▸ MAPK1 P28482 2/20 0.39
▸ AKR1C3 P42330 1/20 0.39
▸ USP2 O75604 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ GLA P06280 1/20 0.39
▸ SYK P43405 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ TSHR P16473 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20141514 0.88 NOTUM (0.48) NOTUMCA12CA1CA2CA9
SCHEMBL20141208 0.86 MEN1 (0.40) NOTUMALDH1A1LMNAMTORRPTOR
SCHEMBL20142447 0.82 SCN9A (0.40) NOTUMCA12CA1CA2CA9
SCHEMBL21360401 0.80 GPR119 (0.45) ALDH1A1LMNAPOLBMEN1KMT2A
SCHEMBL21360404 0.80 GPR119 (0.45) ALDH1A1LMNAPOLBMEN1KMT2A
SCHEMBL20141063 0.78 RORC (0.42) NOTUMCA12CA1CA2CA9
SCHEMBL3047808 0.77 SCN9A (0.49) NOTUMALDH1A1MAPK1SYKTSHR
SCHEMBL21831876 0.76 DPP8 (0.43) LMNAMTORSMN1; SMN2MAPK1TSHR
SCHEMBL21360376 0.73 FPR2 (0.52) NOTUMFPR2SCN9A
SCHEMBL13734773 0.73 GFER (0.56) CA12CA1CA2CA9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR NOTUM 1789/4885CA12 4849/4885CA1 4540/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR NOTUM 1789/4885CA12 4849/4885CA1 4540/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR NOTUM 1789/4885CA12 4849/4885CA1 4540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.