Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140992 | 0.88 | NOTUM (0.42) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL20141914 | 0.85 | AGTR2 (0.44) | NOTUMALDH1A1LMNAMAPK1AKR1C3 | |
| SCHEMBL23198268 | 0.85 | AGTR2 (0.44) | NOTUMALDH1A1LMNAMAPK1AKR1C3 | |
| SCHEMBL20141927 | 0.85 | AGTR2 (0.44) | NOTUMALDH1A1LMNAMAPK1AKR1C3 | |
| SCHEMBL20142447 | 0.84 | SCN9A (0.40) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL5384801 | 0.81 | MEN1 (0.46) | ALDH1A1LMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL20142045 | 0.81 | MEN1 (0.46) | ALDH1A1LMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL20141063 | 0.81 | RORC (0.42) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL20458161 | 0.80 | NOTUM (0.53) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL9891645 | 0.80 | NOTUM (0.53) | NOTUMCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |