Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 12/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141301 | 0.85 | MAPK1 (0.42) | RORCADAMTS5MMP14LMNAMAPT | |
| SCHEMBL20141063 | 0.84 | RORC (0.42) | RORCADAMTS5SMN1; SMN2LMNA | |
| SCHEMBL21360345 | 0.83 | TP53 (0.47) | ADAMTS5MMP2LMNA | |
| SCHEMBL23777576 | 0.82 | ADAMTS5 (0.57) | ADAMTS5MMP2MMP14MMP13SMN1; SMN2 | |
| SCHEMBL23777577 | 0.82 | ADAMTS5 (0.57) | ADAMTS5MMP2MMP14MMP13SMN1; SMN2 | |
| SCHEMBL20141224 | 0.77 | KDM4E (0.46) | SMN1; SMN2NPC1LMNAMAPTTSHR | |
| SCHEMBL14921000 | 0.76 | ADAMTS5 (0.47) | ADAMTS5MMP2MMP14ENPP2SMN1; SMN2 | |
| SCHEMBL27690557 | 0.75 | HTR2A (0.46) | BPTF | |
| SCHEMBL20141303 | 0.74 | MAPK1 (0.43) | ADAMTS5MMP2LMNAMAPT | |
| SCHEMBL631955 | 0.73 | SMN1; SMN2 (0.59) | ADAMTS5MMP2ENPP2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |