Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141301 | 0.82 | MAPK1 (0.42) | KMT2AMEN1TSHRNOTUMLMNA | |
| SCHEMBL20141154 | 0.82 | GRM1 (0.48) | KDM4E | |
| SCHEMBL21360309 | 0.81 | SCN9A (0.46) | KMT2AMEN1TSHRLMNAMAPT | |
| SCHEMBL20140930 | 0.80 | GAA (0.38) | TSHRSMN1; SMN2GAA | |
| SCHEMBL20141063 | 0.79 | RORC (0.42) | ALOX15NOTUMLMNASMN1; SMN2GAA | |
| SCHEMBL26112312 | 0.78 | ALDH1A1 (0.46) | KMT2AMEN1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL26112304 | 0.78 | ALDH1A1 (0.46) | KMT2AMEN1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL20141040 | 0.77 | RORC (0.43) | TSHRLMNAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL20141307 | 0.76 | GRM1 (0.46) | KDM4EKMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL3169375 | 0.74 | CCNE2 (0.42) | KDM4EKMT2AMEN1NOTUMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |