Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141301 | 0.88 | MAPK1 (0.42) | MAPK1ADAMTS5NOTUMMAPTLMNA | |
| SCHEMBL21360343 | 0.82 | GPR119 (0.50) | — | |
| SCHEMBL6904992 | 0.78 | MAPK1 (0.55) | MAPK1ADAMTS5MAPTLMNAMMP2 | |
| SCHEMBL20141248 | 0.78 | CACNA1G (0.39) | MAPK1ADAMTS5MAPTLMNAALDH1A1 | |
| SCHEMBL23496804 | 0.77 | CA1 (0.65) | CA1CA2CA4CA9LMNA | |
| SCHEMBL29111200 | 0.77 | CA1 (0.65) | CA1CA2CA4CA9LMNA | |
| SCHEMBL23198268 | 0.76 | AGTR2 (0.44) | MAPK1NOTUMMAPTLMNANPSR1 | |
| SCHEMBL20141914 | 0.76 | AGTR2 (0.44) | MAPK1NOTUMMAPTLMNANPSR1 | |
| SCHEMBL20141927 | 0.76 | AGTR2 (0.44) | MAPK1NOTUMMAPTLMNANPSR1 | |
| SCHEMBL20141063 | 0.75 | RORC (0.42) | MAPK1CA1CA2CA9ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |