Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141054 | 0.80 | MTOR (0.48) | SMN1; SMN2LMNATP53ALDH1A1MAPT | |
| SCHEMBL20141253 | 0.78 | TSHR (0.43) | SMN1; SMN2LMNAHTTTP53ALDH1A1 | |
| SCHEMBL20133647 | 0.74 | MTOR (0.58) | KDM4ESMN1; SMN2LMNAHTTTP53 | |
| SCHEMBL20140581 | 0.70 | KDM4E (0.52) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL20141023 | 0.70 | EED (0.45) | KDM4ESMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL20141164 | 0.69 | MTOR (0.46) | LMNATP53ALDH1A1MAPT | |
| SCHEMBL20141263 | 0.69 | MTOR (0.46) | LMNAHTTMAPT | |
| SCHEMBL20140929 | 0.68 | MTOR (0.57) | KDM4ELMNATP53ALDH1A1 | |
| SCHEMBL20140938 | 0.67 | MTOR (0.63) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL20141254 | 0.67 | MTOR (0.53) | KDM4EALDH1A1HSD17B10CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |