Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129702 | 0.77 | PKM (0.37) | PKMPKLRHTT | |
| SCHEMBL4139118 | 0.71 | PKM (0.50) | PKMPKLRKEAP1CES2CES1 | |
| SCHEMBL31046855 | 0.70 | ALB (0.53) | PKMPKLRKEAP1CES2CES1 | |
| SCHEMBL2576801 | 0.70 | ALB (0.53) | PKMPKLRKEAP1CES2CES1 | |
| SCHEMBL22693287 | 0.69 | STS (0.45) | PKMPKLRHTTSMN1; SMN2 | |
| SCHEMBL25388212 | 0.68 | L3MBTL1 (0.38) | PKMTDP1PTGS2ALOX15 | |
| SCHEMBL13784495 | 0.68 | KMT2A (0.45) | — | |
| SCHEMBL25387889 | 0.67 | ALDH1A1 (0.53) | PKMPKLRTDP1 | |
| SCHEMBL14676121 | 0.67 | HSD11B1 (0.47) | PKMPKLRKEAP1SMN1; SMN2ALOX15 | |
| SCHEMBL25386498 | 0.67 | ALDH1A1 (0.53) | PKMPKLRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |