Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.71 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.71 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.71 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157118 | 0.89 | MTOR (0.76) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20140044 | 0.84 | MTOR (0.54) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20157290 | 0.84 | MTOR (0.50) | MTORRPTORMLST8ALDH1A1TSHR | |
| SCHEMBL20159126 | 0.83 | MTOR (1.00) | MTORRPTORMLST8ALDH1A1LMNA | |
| SCHEMBL20140693 | 0.81 | HCRTR1 (0.49) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20156931 | 0.80 | MTOR (0.51) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20157066 | 0.80 | MTOR (0.46) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20157539 | 0.79 | MTOR (0.46) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20139924 | 0.79 | MTOR (0.61) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20140600 | 0.78 | KDM4E (0.54) | MTORRPTORMLST8PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |