Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 8/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140044 | 0.92 | MTOR (0.54) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20157021 | 0.91 | SLC6A7 (0.46) | HCRTR1HCRTR2GBA1MTORRPTOR | |
| SCHEMBL20157539 | 0.88 | MTOR (0.46) | MTORRPTORMLST8PHGDHPARP1 | |
| SCHEMBL20140158 | 0.88 | MTOR (0.51) | HCRTR1HCRTR2GBA1MTORRPTOR | |
| SCHEMBL20141809 | 0.87 | GBA1 (0.44) | HCRTR1HCRTR2GBA1MTORRPTOR | |
| SCHEMBL20156931 | 0.87 | MTOR (0.51) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20140785 | 0.87 | PARP1 (0.47) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20156809 | 0.86 | MTOR (0.45) | MTORRPTORMLST8PHGDHPARP1 | |
| SCHEMBL20140472 | 0.86 | PARP1 (0.46) | HCRTR1HCRTR2GBA1MTORRPTOR | |
| SCHEMBL20140600 | 0.85 | KDM4E (0.54) | MTORRPTORMLST8PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |