Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141438 | 0.83 | MTOR (0.45) | MTORRPTORMLST8SLC6A7 | |
| SCHEMBL21360322 | 0.82 | GPR119 (0.56) | GRM1MTORRPTORMLST8 | |
| SCHEMBL20141053 | 0.82 | SLC6A7 (0.40) | GRM1KDM4ESLC6A7KMT2A | |
| SCHEMBL20140855 | 0.81 | GRM1 (0.67) | GRM1KDM4EHSD17B10HPGDCYP3A4 | |
| SCHEMBL20141301 | 0.80 | MAPK1 (0.42) | ALDH1A1TSHRLMNAMAPK1KMT2A | |
| SCHEMBL22159416 | 0.80 | GRM1 (0.41) | GRM1KDM4EHSD17B10HPGDCYP3A4 | |
| SCHEMBL20141224 | 0.76 | KDM4E (0.46) | KDM4EHSD17B10CYP2C9ALDH1A1TSHR | |
| SCHEMBL20141319 | 0.75 | LMNA (0.45) | LMNASMN1; SMN2KMT2A | |
| SCHEMBL16653814 | 0.75 | CHRM4 (0.41) | ALDH1A1TSHRSLC6A7 | |
| SCHEMBL8326245 | 0.75 | SYK (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |