Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 3/20 | 0.31 |
| ▸ | NOS1 | P29475 | 3/20 | 0.31 |
| ▸ | NOS2 | P35228 | 3/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141101 | 0.90 | CHEK1 (0.36) | TP53THRBMTORRPTORMLST8 | |
| SCHEMBL20141405 | 0.87 | NOTUM (0.38) | SLC6A2SLC6A4SLC6A3MTORRPTOR | |
| SCHEMBL20140898 | 0.80 | SLC6A4 (0.41) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL20141281 | 0.77 | MTOR (0.35) | SLC6A2SLC6A4SLC6A3MTORRPTOR | |
| SCHEMBL20141180 | 0.77 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL20141353 | 0.77 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL20141195 | 0.77 | MTOR (0.51) | TP53MTORRPTORMLST8 | |
| SCHEMBL20141074 | 0.75 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3NOS2NOTUM | |
| SCHEMBL20141214 | 0.74 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL20141216 | 0.74 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |