Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 3/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141483 | 0.90 | TP53 (0.32) | TP53THRBMTORRPTORMLST8 | |
| SCHEMBL20141281 | 0.88 | MTOR (0.35) | CHEK1KCNH2CHEK2HPGDKDM4E | |
| SCHEMBL20141029 | 0.81 | SLC6A2 (0.38) | CHEK1KCNH2CHEK2HPGDKDM4E | |
| SCHEMBL20140933 | 0.79 | SLC6A2 (0.36) | CHEK1CHEK2HPGDKDM4EALDH1A1 | |
| SCHEMBL20141030 | 0.79 | SLC6A2 (0.38) | CHEK1CHEK2HPGDKDM4EALDH1A1 | |
| SCHEMBL20141405 | 0.77 | NOTUM (0.38) | MTORRPTORMLST8 | |
| SCHEMBL20141049 | 0.76 | SLC6A2 (0.38) | CHEK1KCNH2CHEK2ALDH1A1 | |
| SCHEMBL20141036 | 0.76 | KCNH2 (0.37) | CHEK1KCNH2HPGDKDM4EALDH1A1 | |
| SCHEMBL20141038 | 0.76 | KCNH2 (0.37) | CHEK1KCNH2HPGDKDM4EALDH1A1 | |
| SCHEMBL20141147 | 0.75 | SLC6A2 (0.38) | CHEK1KCNH2CHEK2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |