Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 7/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140777 | 0.96 | DRD4 (0.43) | DRD4MTORRPTORMLST8HCRTR1 | |
| SCHEMBL20156808 | 0.85 | MTOR (0.38) | DRD4MTORRPTORMLST8PDE2A | |
| SCHEMBL20156963 | 0.83 | GBA1 (0.45) | MTORRPTORMLST8GBA1 | |
| SCHEMBL20140304 | 0.83 | GBA1 (0.44) | DRD4MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20139895 | 0.81 | DRD4 (0.46) | DRD4MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20157068 | 0.81 | DRD4 (0.46) | DRD4ALDH1A1KDM4EHTT | |
| SCHEMBL20140897 | 0.81 | MTOR (0.45) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20157066 | 0.80 | MTOR (0.46) | DRD4MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20157255 | 0.79 | MTOR (0.40) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20140318 | 0.79 | KDM5A (0.45) | DRD4MTORRPTORMLST8HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |