Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 7/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140096 | 0.90 | PARP1 (0.45) | MTORRPTORMLST8PARP1CYP46A1 | |
| SCHEMBL20156963 | 0.85 | GBA1 (0.45) | MTORRPTORMLST8PARP1PHGDH | |
| SCHEMBL20140304 | 0.85 | GBA1 (0.44) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20140897 | 0.82 | MTOR (0.45) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20140648 | 0.82 | PRMT5 (0.42) | MTORRPTORMLST8CYP46A1ALDH1A1 | |
| SCHEMBL20140777 | 0.80 | DRD4 (0.43) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20140733 | 0.80 | KDM4E (0.48) | ALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL20141538 | 0.79 | DRD4 (0.41) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20140725 | 0.78 | MTOR (0.47) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20140044 | 0.77 | MTOR (0.54) | MTORRPTORMLST8PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |