Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.38 |
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141654 | 1.00 | HDAC1 (0.47) | HDAC1MAP4K4GPR119HTR1AACACB | |
| SCHEMBL20139744 | 0.83 | MAP4K4 (0.46) | HDAC1MAP4K4GPR119SUV39H2NR1H2 | |
| SCHEMBL28520979 | 0.81 | MAP4K4 (0.49) | HDAC1MAP4K4GPR119SUV39H2NR1H2 | |
| SCHEMBL17114986 | 0.80 | MAP4K4 (0.47) | HDAC1MAP4K4GPR119SUV39H2NR1H2 | |
| SCHEMBL17114988 | 0.80 | MAP4K4 (0.47) | HDAC1MAP4K4GPR119SUV39H2NR1H2 | |
| SCHEMBL23602022 | 0.79 | MAP4K4 (0.53) | HDAC1MAP4K4GPR119HTR1ASUV39H2 | |
| SCHEMBL20831929 | 0.77 | TRPC5 (0.46) | HDAC1MAP4K4GPR119SUV39H2IDO1 | |
| SCHEMBL13999776 | 0.77 | HDAC1 (0.49) | HDAC1MAP4K4GPR119NR1H2NR1H3 | |
| SCHEMBL29799403 | 0.76 | DRD2 (0.50) | HDAC1MAP4K4GPR119SUV39H2 | |
| SCHEMBL24719091 | 0.76 | DRD2 (0.50) | HDAC1MAP4K4GPR119SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |