Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369046 | 0.76 | ESR2 (0.70) | NOTUMMAPTMEN1KMT2ATAAR1 | |
| SCHEMBL1202402 | 0.76 | ESR2 (0.70) | NOTUMMAPTMEN1KMT2ATAAR1 | |
| Ammonia Solution, Strong SCHEMBL30461763 | 0.75 | ESR2 (0.68) | NOTUMMAPTMEN1KMT2ATAAR1 | |
| Formamide SCHEMBL18787605 | 0.73 | NR1H2 (0.64) | NOTUMMAPTMEN1KMT2ATAAR1 | |
| SCHEMBL507146 | 0.73 | NR1H2 (0.61) | NOTUMESR2PRMT5WDR77MAPK1 | |
| SCHEMBL27929852 | 0.72 | NOTUM (0.45) | NOTUMDRD2LIPEMAPTMEN1 | |
| SCHEMBL2014179 | 0.72 | DRD2 (0.56) | DRD2MAPTMEN1KMT2APRMT5 | |
| SCHEMBL4026764 | 0.71 | HPGD (0.39) | — | |
| SCHEMBL4180059 | 0.71 | CTSK (0.41) | MAPTMEN1KMT2A | |
| SCHEMBL14558091 | 0.71 | RIPK1 (0.67) | NOTUMRIPK1ESR2PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073269-A1 | PIPERIDINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073276-A1 | BENZOXAZINE ARYL SULFONAMIDE DERIVATIVES AS KV1.3 MODULATORS | EVOTEC AG (DE) | 2011-06-23 | — | — | WO | disclosed |