Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159390 | 0.91 | PDE4D (0.38) | PDE3BPDE3AHRH3PDE4DPDE4A | |
| SCHEMBL20159105 | 0.88 | CES2 (0.43) | PDE3BPDE3AHRH3PDE4DPDE4A | |
| SCHEMBL20159214 | 0.88 | HRH3 (0.41) | PDE3BPDE3AHRH3PDE4DPDE4A | |
| SCHEMBL20138907 | 0.85 | PDE4A (0.40) | PDE3BPDE3AHRH3PDE4DPDE4A | |
| SCHEMBL20159213 | 0.85 | PDE4A (0.40) | PDE3BPDE3AHRH3PDE4DPDE4A | |
| SCHEMBL20142922 | 0.85 | PDE4A (0.40) | PDE3BPDE3AHRH3PDE4DPDE4A | |
| SCHEMBL20138813 | 0.78 | PDE4A (0.40) | PDE3BPDE3APDE4DPDE4APDE4B | |
| SCHEMBL20142927 | 0.78 | PDE4A (0.40) | PDE3BPDE3APDE4DPDE4APDE4B | |
| SCHEMBL20159190 | 0.78 | PDE4A (0.40) | PDE3BPDE3APDE4DPDE4APDE4B | |
| SCHEMBL20159391 | 0.73 | PDE4A (0.38) | PDE3BPDE3AGAAHRH3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |