Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.38 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.38 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28752642 | 0.95 | LMNA (0.55) | LMNATDP1MCL1POLBALDH1A1 | |
| SCHEMBL30481108 | 0.95 | LMNA (0.55) | LMNATDP1MCL1POLBALDH1A1 | |
| SCHEMBL28752643 | 0.93 | TDP1 (0.56) | LMNATDP1MCL1POLBALDH1A1 | |
| SCHEMBL28645928 | 0.89 | MCL1 (0.47) | LMNATDP1MCL1POLBALDH1A1 | |
| SCHEMBL9623098 | 0.85 | KMT2A (0.50) | LMNAPOLBALDH1A1PKMTSHR | |
| SCHEMBL4664314 | 0.84 | LMNA (0.54) | LMNATDP1MCL1ALDH1A1PTGS2 | |
| SCHEMBL10187523 | 0.82 | MCL1 (0.50) | LMNAMCL1POLBALDH1A1NPC1 | |
| SCHEMBL14604980 | 0.82 | MCL1 (0.50) | LMNAMCL1POLBALDH1A1NPC1 | |
| SCHEMBL18192045 | 0.82 | MCL1 (0.50) | LMNAMCL1POLBALDH1A1NPC1 | |
| SCHEMBL7214832 | 0.81 | MCL1 (0.47) | LMNATDP1MCL1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969739-B2 | Tricyclic chiral compounds and their use in asymmetric catalysis | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2018-05-15 | — | — | US | disclosed |