Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2868266 | 0.85 | TSHR (0.40) | MEN1MAPK1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL19928063 | 0.83 | ACHE (0.41) | ACHERAB9ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL1704315 | 0.79 | KCNN4 (0.41) | ACHERAB9ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL1704452 | 0.79 | KCNN4 (0.41) | ACHERAB9ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL1832344 | 0.79 | RAB9A (0.45) | ACHERAB9ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL1835661 | 0.79 | RAB9A (0.45) | ACHERAB9ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL28835171 | 0.78 | RAB9A (0.43) | ACHERAB9ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL24816539 | 0.77 | KIF11 (0.44) | RAB9AMEN1NPC1KMT2ACYP3A4 | |
| SCHEMBL4348723 | 0.77 | ESR1 (0.52) | ACHERAB9ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL12640840 | 0.77 | TSHR (0.55) | ACHERAB9ANPC1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969689-B2 | Aryl ethers and uses thereof | PELOTON THERAPEUTICS, INC. (US) | 2018-05-15 | — | — | US | disclosed |