Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016659 | 1.00 | JAK1 (0.39) | JAK1CHEK1NTRK1FYNRET | |
| SCHEMBL2015268 | 0.95 | CHEK1 (0.40) | CHEK1NTRK1FYNRETMET | |
| SCHEMBL2014352 | 0.84 | NPC1 (0.41) | JAK1KMT2ANPSR1MEN1ALDH1A1 | |
| SCHEMBL2163969 | 0.83 | NPC1 (0.43) | JAK1CDK8KMT2ANPSR1MEN1 | |
| SCHEMBL2011479 | 0.82 | METAP2 (0.43) | METAP2KMT2ANPSR1MEN1ALDH1A1 | |
| SCHEMBL2011476 | 0.82 | METAP2 (0.43) | METAP2KMT2ANPSR1MEN1ALDH1A1 | |
| SCHEMBL2013328 | 0.82 | L3MBTL1 (0.45) | CDK8AURKBMETAP2KMT2ANPSR1 | |
| SCHEMBL2011741 | 0.81 | METAP2 (0.42) | METAP2KMT2ANPSR1MEN1ALDH1A1 | |
| SCHEMBL2015791 | 0.81 | METAP2 (0.42) | METAP2KMT2ANPSR1MEN1ALDH1A1 | |
| SCHEMBL2013778 | 0.80 | NPC1 (0.44) | METAP2KMT2ANPSR1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |