Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014360 | 0.88 | PPARG (0.45) | PPARGLMNAALDH1A1TP53MAPK1 | |
| SCHEMBL2016383 | 0.84 | PPARG (0.40) | PPARGALDH1A1KMT2AMEN1PKM | |
| SCHEMBL2018088 | 0.83 | TNF (0.53) | KDM4ETNFTSHRPOLBKMT2A | |
| SCHEMBL12210796 | 0.82 | ALDH1A1 (0.53) | PPARGLMNAALDH1A1TP53MAPK1 | |
| SCHEMBL22031586 | 0.82 | GLA (0.49) | PPARGKDM4EKMT2AMEN1PKM | |
| SCHEMBL6242878 | 0.81 | MAPK1 (0.50) | PPARGLMNAALDH1A1TP53MAPK1 | |
| SCHEMBL2020767 | 0.81 | ACSS2 (0.54) | LMNATP53KDM4ETNFTSHR | |
| SCHEMBL30698370 | 0.81 | MAPT (0.45) | PPARGLMNAALDH1A1TP53MAPK1 | |
| SCHEMBL4777935 | 0.81 | MAPT (0.45) | PPARGLMNAALDH1A1TP53MAPK1 | |
| SCHEMBL12290595 | 0.80 | ALDH1A1 (0.41) | PPARGLMNAALDH1A1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |