Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 12/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22877119 | 0.83 | GABBR2 (0.47) | HCRTR1 | |
| SCHEMBL20145210 | 0.81 | IL1B (0.49) | IL1BNLRP3KAT2BBPTF | |
| SCHEMBL20145261 | 0.78 | IL1B (0.55) | IL1BNLRP3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20144869 | 0.78 | IL1B (0.55) | IL1BNLRP3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL26437563 | 0.77 | IL1B (0.75) | IL1BNLRP3 | |
| SCHEMBL22877073 | 0.75 | KMT2A (0.44) | HCRTR1 | |
| SCHEMBL27291019 | 0.74 | IL1B (0.56) | IL1BNLRP3 | |
| SCHEMBL26436779 | 0.74 | NLRP3 (0.64) | IL1BNLRP3 | |
| SCHEMBL25797910 | 0.74 | IL1B (0.84) | IL1BNLRP3 | |
| SCHEMBL26436520 | 0.74 | NLRP3 (0.77) | IL1BNLRP3KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |