Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 11/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 5/20 | 0.45 |
| ▸ | BPTF | Q12830 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CCNH | P51946 | 1/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145261 | 0.83 | IL1B (0.55) | IL1BNLRP3CCNKCDK2CDK12 | |
| SCHEMBL20144869 | 0.83 | IL1B (0.55) | IL1BNLRP3CCNKCDK2CDK12 | |
| SCHEMBL24968865 | 0.82 | IDH2 (0.54) | CCNKCCNE1CDK2CDK12 | |
| SCHEMBL25596437 | 0.81 | CDK7 (0.52) | IL1BNLRP3CDK7CCNHMNAT1 | |
| SCHEMBL20144776 | 0.81 | IL1B (0.53) | IL1BNLRP3KAT2BBPTF | |
| SCHEMBL18607391 | 0.80 | ULK1 (0.55) | — | |
| SCHEMBL15951534 | 0.80 | CDK7 (0.51) | IL1BNLRP3KAT2BBPTFCDK7 | |
| SCHEMBL11989612 | 0.78 | HRH4 (0.45) | IL1BNLRP3KAT2BBPTFCCNT1 | |
| SCHEMBL25226590 | 0.78 | MAPK3 (0.50) | CCNKCDK12 | |
| SCHEMBL16187048 | 0.77 | IL1B (0.53) | IL1BNLRP3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |