Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1289874 | 0.82 | ALDH1A1 (0.42) | IL2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4408061 | 0.79 | KDM4E (0.43) | IL2BRD4PIK3CDPIK3CGHPGDS | |
| SCHEMBL17102182 | 0.79 | BRD4 (0.38) | HCRTR1HCRTR2IL2TUBB4ATUBB | |
| SCHEMBL31039212 | 0.79 | ADRA1A (0.47) | ADRA1AHCRTR1HCRTR2ADRA2AADRA1D | |
| SCHEMBL7834048 | 0.79 | ADRA1A (0.48) | ADRA1AHCRTR1HCRTR2ADRA2AADRA1D | |
| SCHEMBL14108017 | 0.77 | HCRTR1 (0.46) | ADRA1AHCRTR1HCRTR2NISCHADRA2A | |
| SCHEMBL16149099 | 0.76 | HCRTR1 (0.52) | ADRA1AHCRTR1HCRTR2ADRA2AADRA1D | |
| SCHEMBL3031254 | 0.74 | RAB9A (0.53) | ADRA1AADRA2AADRA1DADRA1BBRD4 | |
| SCHEMBL4265596 | 0.73 | ALDH1A1 (0.49) | PDE2A | |
| SCHEMBL22187760 | 0.72 | CTSA (0.44) | ADRA1AHCRTR1HCRTR2ADRA2AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |