Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144818 | 0.81 | IL1B (0.50) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL20145059 | 0.81 | L3MBTL1 (0.49) | L3MBTL1POLBCHRM2CHRM1CHRM3 | |
| SCHEMBL20145073 | 0.81 | IL1B (0.50) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL13161940 | 0.74 | CHRM4 (0.43) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL23027707 | 0.73 | POLB (0.41) | L3MBTL1POLBCHRM2CHRM1CHRM3 | |
| SCHEMBL17581176 | 0.73 | CHRM2 (0.43) | L3MBTL1POLBCHRM2CHRM1CHRM3 | |
| SCHEMBL23027705 | 0.73 | CHRM2 (0.44) | L3MBTL1POLBCHRM2CHRM1CHRM3 | |
| SCHEMBL17581293 | 0.72 | POLB (0.38) | L3MBTL1POLBCHRM2CHRM1CHRM3 | |
| SCHEMBL932866 | 0.71 | CHRM4 (0.40) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL23373228 | 0.71 | L3MBTL1 (0.58) | L3MBTL1POLBHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |