Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | IL1B | P01584 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145182 | 0.87 | IL1B (0.46) | IL1BNLRP3SSTR4PTK2HCRTR1 | |
| SCHEMBL20145073 | 0.80 | IL1B (0.50) | IL1BNLRP3HCRTR1HCRTR2 | |
| SCHEMBL20144818 | 0.80 | IL1B (0.50) | IL1BNLRP3HCRTR1HCRTR2 | |
| SCHEMBL28682548 | 0.77 | MEN1 (0.40) | KMT2ASMN1; SMN2LMNACYP2C19HPGD | |
| SCHEMBL20145221 | 0.77 | IL1B (0.55) | IL1BNLRP3HCRTR1 | |
| SCHEMBL20144750 | 0.77 | IL1B (0.55) | IL1BNLRP3HCRTR1 | |
| SCHEMBL28689183 | 0.76 | MEN1 (0.41) | KMT2ASMN1; SMN2LMNACYP2C19HPGD | |
| SCHEMBL31695270 | 0.76 | PIK3CD (0.55) | KMT2AMEN1 | |
| SCHEMBL29993940 | 0.75 | CYP2C19 (0.48) | KMT2ASMN1; SMN2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL29935443 | 0.75 | PIK3CD (0.52) | KMT2ASMN1; SMN2CYP2C19MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |