Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 1/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.52 |
| ▸ | LIPE | Q05469 | 9/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144750 | 1.00 | IL1B (0.55) | IL1BNLRP3LIPGLIPEHSD11B1 | |
| SCHEMBL20145199 | 0.92 | LIPE (0.55) | IL1BNLRP3LIPGLIPEHSD11B1 | |
| SCHEMBL20145024 | 0.83 | TDO2 (0.48) | IL1BNLRP3 | |
| SCHEMBL20144818 | 0.83 | IL1B (0.50) | IL1BNLRP3HCRTR1 | |
| SCHEMBL20145073 | 0.83 | IL1B (0.50) | IL1BNLRP3HCRTR1 | |
| SCHEMBL20145106 | 0.82 | LIPG (0.53) | LIPGLIPEHSD11B1HCRTR1 | |
| SCHEMBL18855867 | 0.82 | LIPE (0.53) | LIPGLIPEHSD11B1 | |
| SCHEMBL30755072 | 0.81 | LIPE (0.52) | LIPGLIPEHSD11B1 | |
| SCHEMBL16839482 | 0.81 | LIPE (0.52) | LIPGLIPEHSD11B1 | |
| SCHEMBL20145101 | 0.81 | IL1B (0.46) | IL1BNLRP3HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |