Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11678758 | 0.74 | BCHE (0.61) | BCHEHTR2AHTR2CDRD2CHRNA7 | |
| SCHEMBL9027033 | 0.74 | HTR2A (0.65) | BCHEHTR2AHTR2CDRD2CHRNA7 | |
| SCHEMBL9026523 | 0.73 | HTR2A (0.66) | BCHEHTR2AHTR2CDRD2CHRNA7 | |
| SCHEMBL11260031 | 0.70 | SIGMAR1 (0.55) | BCHEDRD2CHRNA7KMT2ASIGMAR1 | |
| SCHEMBL11680166 | 0.69 | BCHE (0.48) | BCHEHTR2AHTR2CDRD2CHRNA7 | |
| SCHEMBL9866577 | 0.69 | SIGMAR1 (0.79) | SCN5AHRH3SIGMAR1 | |
| SCHEMBL14193990 | 0.68 | CHRNB2 (0.64) | BCHEHTR2AHTR2CCHRNA7CHRNB2 | |
| SCHEMBL6882102 | 0.68 | HTT (0.55) | BCHEHTR2AHTR2CDRD2CHRNA7 | |
| SCHEMBL11415261 | 0.67 | KDM4E (0.56) | BCHECHRNA7CHRNB2CHRNA4HTT | |
| SCHEMBL16511543 | 0.67 | SCN5A (0.72) | SCN5AHRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013824-B1 | CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ALZPROTECT (FR) | 2018-05-16 | — | — | EP | disclosed |