SCHEMBL20146223

SCHEMBL20146223

C=CCOC(=O)NCCCc1ccccc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 3/20 0.47
CASP1 P29466 5/20 0.44
TGM2 P21980 1/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
NCOR2 Q9Y618 1/20 0.41
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
FAAH O00519 1/20 0.40
CHRNB2 P17787 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9488115 0.81 CASP1 (0.62) CASP1TGM2HDAC3HDAC4HDAC1
SCHEMBL27399235 0.77 NQO2 (0.49) MEN1KMT2A
SCHEMBL1821309 0.76 HIF1A (0.50) ERN1CASP1CYP3A4HPGDALDH1A1
SCHEMBL28233273 0.75 SMN1; SMN2 (0.57) HPGDSMN1; SMN2L3MBTL1
SCHEMBL20146220 0.74 CASP1 (0.38) CASP1CYP3A4ALDH1A1MAPTKMT2A
SCHEMBL17108610 0.74 CASP1 (0.38) CASP1CYP3A4ALDH1A1MAPTKMT2A
SCHEMBL17108608 0.74 CASP1 (0.38) CASP1CYP3A4ALDH1A1MAPTKMT2A
SCHEMBL3676772 0.73 TGM2 (0.46) ERN1TGM2
SCHEMBL7113446 0.73 CYP3A4 (0.49) CYP3A4HPGDSMN1; SMN2ALDH1A1MEN1
SCHEMBL15830408 0.72 MEN1 (0.56) HPGDALDH1A1MEN1MAPTALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3119752-B1 3,4-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF ENAC MEDIATED DISEASES ASTRAZENECA AB (SE) 2018-05-16 EP disclosed