Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13969531 | 0.88 | PDK1 (0.48) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL28644186 | 0.85 | AGTR2 (0.54) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL28727195 | 0.85 | PDK1 (0.44) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL31107783 | 0.83 | HTR2C (0.54) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL14544848 | 0.83 | AGTR2 (0.44) | PDK1PDK2PDK3PDK4AGTR2 | |
| SCHEMBL13201874 | 0.83 | AGTR2 (0.44) | PDK1PDK2PDK3PDK4AGTR2 | |
| SCHEMBL20992001 | 0.83 | CTSL (0.48) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL2678879 | 0.83 | CTSL (0.48) | PDK1PDK2PDK3PDK4AGTR2 | |
| SCHEMBL11931411 | 0.82 | PREP (0.48) | FKBP1APREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27190346 | 0.82 | PREP (0.48) | FKBP1APREPNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3560932-B1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES OF SAME | JAPAN TOBACCO INC (JP) | 2026-03-11 | — | — | EP | disclosed |
| US-20250084106-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF | LEO PHARMA A/S (DK) | 2025-03-13 | — | — | US | disclosed |
| US-12195481-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof | JAPAN TOBACCO INC. (JP) | 2025-01-14 | — | — | US | disclosed |
| EP-3321271-B1 | METHOD FOR PRODUCING 7H-PYRROLO[2, 3-D]PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF | JAPAN TOBACCO INC (JP) | 2024-05-29 | — | — | EP | disclosed |
| US-20240140967-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF | LEO PHARMA A/S (DK) | 2024-05-02 | — | — | US | disclosed |
| CN-117865992-A | Process for preparing 7H-pyrrolo [2,3-d ] pyrimidine derivatives and synthetic intermediates therefor | 日本烟草产业株式会社 | 2024-04-12 | — | — | CN | disclosed |
| CN-110300756-B | Process for preparing 7H-pyrrolo [2,3-d ] pyrimidine derivatives and synthetic intermediates therefor | 日本烟草产业株式会社 | 2024-01-02 | — | — | CN | disclosed |
| US-11673900-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof | JAPAN TOBACCO INC. (JP) | 2023-06-13 | — | — | US | disclosed |
| US-11673900-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof | JAPAN TOBACCO INC. (JP) | 2023-06-13 | — | — | US | disclosed |
| US-11673900-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof | JAPAN TOBACCO INC. (JP) | 2023-06-13 | — | — | US | disclosed |
| CN-110099910-B | Preparation method of 7H-pyrrolo [2,3-d ] pyrimidine derivative and eutectic crystal thereof | 日本烟草产业株式会社 | 2022-12-20 | — | — | CN | disclosed |
| US-11339181-B2 | Crystalline forms of a Janus kinase inhibitor | JAPAN TOBACCO INC. (JP) | 2022-05-24 | — | — | US | disclosed |
| US-11339181-B2 | Crystalline forms of a Janus kinase inhibitor | JAPAN TOBACCO INC. (JP) | 2022-05-24 | — | — | US | disclosed |
| US-11312728-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and co-crystals thereof | JAPAN TOBACCO INC. (JP) | 2022-04-26 | — | — | US | disclosed |
| US-11312728-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and co-crystals thereof | JAPAN TOBACCO INC. (JP) | 2022-04-26 | — | — | US | disclosed |
| US-10822354-B2 | Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof | JAPAN TOBACCO INC. (JP) | 2020-11-03 | — | — | US | disclosed |
| US-20200216470-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF | JAPAN TOBACCO INC. (JP) | 2020-07-09 | — | — | US | disclosed |
| US-20200165269-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND CO-CRYSTALS THEREOF | SHIONOGI & CO., LTD. (JP) | 2020-05-28 | — | — | US | disclosed |
| WO-2018117153-A1 | CRYSTALLINE FORMS OF A JANUS KINASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2018-06-28 | — | — | WO | disclosed |
| EP-3321271-A1 | METHOD FOR PRODUCING 7H-PYRROLO[2, 3-D]PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF | Japan Tobacco, Inc. (JP) | 2018-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312728-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and co-crystals thereof | JAK1, JAK3, JAK2 | PDK1 192/4885PDK2 185/4885PDK3 190/4885 |
| US-11673900-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof | JAK1, JAK3, JAK2 | PDK1 117/4885PDK2 167/4885PDK3 259/4885 |
| US-11339181-B2 | Crystalline forms of a Janus kinase inhibitor | JAK1, JAK3, JAK2 | PDK1 854/4885PDK2 1379/4885PDK3 1327/4885 |
| US-20200216470-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF | JAK1, JAK3, JAK2 | PDK1 117/4885PDK2 167/4885PDK3 259/4885 |
| US-12195481-B2 | Process for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof | JAK1, JAK3, JAK2 | PDK1 117/4885PDK2 167/4885PDK3 259/4885 |
| US-20240140967-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF | JAK1, JAK3, JAK2 | PDK1 117/4885PDK2 167/4885PDK3 259/4885 |
| US-10822354-B2 | Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof | JAK1, JAK3, JAK2 | PDK1 184/4885PDK2 208/4885PDK3 285/4885 |
| US-20250084106-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF | JAK1, JAK3, JAK2 | PDK1 117/4885PDK2 167/4885PDK3 259/4885 |
| US-20200165269-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND CO-CRYSTALS THEREOF | JAK1, JAK3, JAK2 | PDK1 192/4885PDK2 185/4885PDK3 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.