SCHEMBL20146336

SCHEMBL20146336

c1ccc([SiH](c2ccccc2)C2CCCOC2)cc1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.33
LTA4H P09960 1/20 0.32
GAA P10253 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
LMNA P02545 1/20 0.31
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15186488 0.78 POLB (0.35) GAA
SCHEMBL28375039 0.76 LMNA (0.39) SMN1; SMN2LMNA
SCHEMBL15914974 0.76 EPHX2 (0.36) GAATAAR1
SCHEMBL18860237 0.73 HRH3 (0.32)
SCHEMBL14849768 0.67 SLC18A3 (0.42) GAA
SCHEMBL7477065 0.67 SLC18A3 (0.42) GAA
SCHEMBL24305874 0.67 AGER (0.39) SMN1; SMN2LMNA
SCHEMBL2931658 0.67 GBA1 (0.47) SMN1; SMN2LMNA
SCHEMBL8074028 0.65
SCHEMBL15914932 0.65 POLB (0.35) GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3374365-A1 METHOD FOR PRODUCING 4-(DIALKYLCHLOROSILYL)-BUTYRONITRILE Wacker Chemie AG (DE) 2018-09-19 EP disclosed
WO-2018086715-A1 METHOD FOR PRODUCING 4-(DIALKYLCHLOROSILYL)-BUTYRONITRILE WACKER CHEMIE AG (DE) 2018-05-17 WO disclosed