Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.34 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014653 | 0.88 | CSNK2A2 (0.39) | CYP17A1CYP3A4CYP11B1CYP11B2CSNK2A2 | |
| SCHEMBL2012666 | 0.85 | TAAR1 (0.47) | TAAR1NT5E | |
| SCHEMBL2017932 | 0.81 | SLC22A12 (0.40) | CYP17A1CYP3A4CYP11B1CYP11B2CSNK2A2 | |
| SCHEMBL12491178 | 0.80 | BCL2 (0.47) | TAAR1CYP17A1CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL2015779 | 0.79 | PIK3CD (0.44) | TAAR1CYP3A4 | |
| SCHEMBL2017066 | 0.78 | TAAR1 (0.43) | TAAR1NT5EDPP4CCNT1CDK9 | |
| SCHEMBL2015153 | 0.76 | BCL2 (0.41) | CYP17A1CYP3A4CYP11B1CYP11B2CSNK2A2 | |
| SCHEMBL2014651 | 0.74 | PIK3CD (0.39) | CYP17A1CYP3A4CYP11B1CYP11B2CSNK2A2 | |
| Trifluoroacetic Acid SCHEMBL2012078 | 0.73 | BCL2 (0.41) | TAAR1CYP3A4NT5E | |
| SCHEMBL12470054 | 0.71 | PIK3CD (0.38) | CYP17A1CYP3A4CYP11B1CYP11B2CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |