Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 9/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015154 | 0.85 | TAAR1 (0.41) | TAAR1NT5E | |
| SCHEMBL2015779 | 0.82 | PIK3CD (0.44) | TAAR1HTR1AKMT2A | |
| SCHEMBL2015782 | 0.80 | NT5E (0.36) | TAAR1NT5EADORA2AKMT2AICMT | |
| SCHEMBL2013334 | 0.79 | TAAR1 (0.48) | TAAR1HTR2AMPOSLC6A4ADORA2A | |
| SCHEMBL12491178 | 0.79 | BCL2 (0.47) | TAAR1HTR2ANT5EMPOTRPM8 | |
| SCHEMBL2017066 | 0.79 | TAAR1 (0.43) | TAAR1NT5EMAOB | |
| SCHEMBL2013052 | 0.78 | TAAR1 (0.47) | TAAR1HTR2ANT5EADORA2AMAOB | |
| SCHEMBL9952729 | 0.75 | PIK3CD (0.44) | TAAR1ADORA2AKMT2A | |
| SCHEMBL9953794 | 0.74 | TAAR1 (0.40) | TAAR1ICMT | |
| SCHEMBL9953176 | 0.73 | LMNA (0.39) | TAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |