Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.43 |
| ▸ | LDHA | P00338 | 3/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481658 | 0.73 | GABRP (0.55) | CAMKK2LDHANEK2RXRBRXRA | |
| SCHEMBL1498034 | 0.67 | RXRB (0.70) | CAMKK2LDHARXRBRXRARARB | |
| SCHEMBL29771992 | 0.67 | RXRB (0.70) | CAMKK2LDHARXRBRXRARARB | |
| SCHEMBL18191217 | 0.65 | ALPL (0.55) | CAMKK2LDHANEK2RXRBRXRA | |
| Hydrochloric Acid SCHEMBL4365452 | 0.65 | RXRB (0.68) | CAMKK2LDHARXRBRXRARARB | |
| Hydrochloric Acid SCHEMBL9150803 | 0.65 | RXRB (0.68) | CAMKK2LDHARXRBRXRARARB | |
| SCHEMBL17177748 | 0.64 | RXRB (0.71) | CAMKK2LDHARXRBRXRARARB | |
| SCHEMBL11517517 | 0.62 | RXRB (0.51) | CAMKK2LDHANEK2RXRBRXRA | |
| SCHEMBL20768653 | 0.62 | HSD17B10 (0.49) | RXRBRXRAGABRPGABRDGABRA1 | |
| SCHEMBL21932509 | 0.62 | HSD17B10 (0.49) | RXRBRXRAGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |