Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.55 |
| ▸ | GABRD | O14764 | 3/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.55 |
| ▸ | GABRE | P78334 | 3/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.55 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 3/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40268 | 0.79 | NPC1 (0.51) | ALOX5APFEN1NPC1 | |
| SCHEMBL15203108 | 0.78 | CSNK2A1 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1498034 | 0.75 | RXRB (0.70) | LDHACAMKK2RXRBRXRAKDM4E | |
| SCHEMBL29771992 | 0.75 | RXRB (0.70) | LDHACAMKK2RXRBRXRAKDM4E | |
| SCHEMBL18191217 | 0.73 | ALPL (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL20146789 | 0.73 | CAMKK2 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Hydrochloric Acid SCHEMBL9150803 | 0.73 | RXRB (0.68) | LDHACAMKK2RXRBRXRAKDM4E | |
| Hydrochloric Acid SCHEMBL4365452 | 0.73 | RXRB (0.68) | LDHACAMKK2RXRBRXRAKDM4E | |
| SCHEMBL6869349 | 0.73 | TDP1 (0.63) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11972504 | 0.72 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |