Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30754057 | 0.84 | HRH3 (0.64) | HRH3KDM1AJAK2JAK1JAK3 | |
| SCHEMBL20148197 | 0.81 | OPRM1 (0.49) | HRH3KDM1AOPRM1OPRK1PARP1 | |
| SCHEMBL31752311 | 0.80 | HRH3 (0.53) | HRH3KDM1AJAK2JAK1JAK3 | |
| SCHEMBL19011600 | 0.78 | HRH3 (0.59) | HRH3KDM1AJAK2JAK1JAK3 | |
| SCHEMBL31747374 | 0.78 | HRH3 (0.57) | HRH3KDM1AJAK2JAK1JAK3 | |
| SCHEMBL6140027 | 0.78 | HRH3 (0.58) | HRH3KDM1AJAK2JAK1JAK3 | |
| SCHEMBL14843687 | 0.78 | HRH3 (0.58) | HRH3KDM1AJAK2JAK1JAK3 | |
| SCHEMBL30754007 | 0.78 | HRH3 (0.58) | HRH3KDM1AJAK2JAK1JAK3 | |
| SCHEMBL30588290 | 0.77 | KDM1A (0.62) | HRH3KDM1AJAK2JAK1JAK3 | |
| Hydrochloric Acid SCHEMBL5009902 | 0.77 | HRH3 (0.57) | HRH3KDM1AJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | RIPK2, RIPK1, RIPK4 | HRH3 3405/4885KDM1A 3027/4885JAK2 888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.