Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160368 | 0.85 | RET (0.47) | RETTRPV6NAAAKDM1AMAOA | |
| SCHEMBL20070741 | 0.84 | TLR7 (0.44) | RETTRPV6KDM1AMAOAMAOB | |
| SCHEMBL20149603 | 0.81 | TRPV6 (0.43) | RETTRPV6NAAAKDM1AMAOA | |
| SCHEMBL22030581 | 0.80 | RET (0.42) | RETTRPV6NAAAKDM1AMAOA | |
| SCHEMBL30248690 | 0.79 | GPR119 (0.47) | RETKDR | |
| SCHEMBL31458788 | 0.79 | GPR119 (0.47) | RETKDR | |
| SCHEMBL20136850 | 0.79 | LTA4H (0.43) | RETTRPV6KDM1AMAOAMAOB | |
| SCHEMBL20148630 | 0.78 | TRPV6 (0.47) | RETTRPV6KDM1AMAOAMAOB | |
| SCHEMBL20148646 | 0.78 | RET (0.46) | RETTRPV6CHRNB2CHRNA4CCDC6 | |
| SCHEMBL20149643 | 0.76 | CHRNB2 (0.56) | RETCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | RET 1/4885TRPV6 4180/4885NAAA 4631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.