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SCHEMBL2014903

SCHEMBL2014903

CC(=O)c1cc(F)c2cccnc2c1OS(=O)(=O)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 6/20 0.41
▸ HSD11B1 P28845 1/20 0.38
▸ PDE4A P27815 3/20 0.38
▸ PDE4C Q08493 3/20 0.38
▸ PDE4D Q08499 3/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ POLB P06746 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ THRB P10828 1/20 0.38
▸ PKM P14618 1/20 0.38
▸ IDO1 P14902 1/20 0.38
▸ RECQL P46063 1/20 0.38
▸ TDO2 P48775 1/20 0.38
▸ BLM P54132 1/20 0.38
▸ CASP6 P55212 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2015964 0.88 BRD4 (0.46) L3MBTL1HSD11B1PDE4APDE4CPDE4D
SCHEMBL2015940 0.87 HIF1A (0.49) L3MBTL1PDE4APDE4CPDE4DKDM4E
SCHEMBL738961 0.78 HTR1A (0.37) L3MBTL1PDE4APDE4CPDE4DKDM4E
SCHEMBL12992671 0.78 BRD4 (0.44) L3MBTL1PDE4APDE4CPDE4DCOMT
SCHEMBL21902372 0.76 KDM4E (0.44) KDM4EMEN1POLBKMT2AALDH1A1
SCHEMBL2015831 0.74 L3MBTL1 (0.60) L3MBTL1KDM4EMEN1POLBKMT2A
SCHEMBL2015013 0.73 HIF1A (0.44) L3MBTL1PDE4APDE4CPDE4DKDM4E
SCHEMBL737308 0.72 SLC40A1 (0.48) L3MBTL1PDE4APDE4CPDE4DKDM4E
SCHEMBL19358748 0.72 ALDH1A1 (0.54) L3MBTL1PDE4APDE4CPDE4DKDM4E
SCHEMBL2014981 0.72 KMT2A (0.42) HSD11B1KDM4EMEN1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8680108-B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors INCYTE CORPORATION (US) 2014-03-25 — — US disclosed
US-8680108-B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors INCYTE CORPORATION (US) 2014-03-25 — — US disclosed
US-8680108-B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors INCYTE CORPORATION (US) 2014-03-25 — — US disclosed
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION 2011-07-28 — — US disclosed
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION 2011-07-28 — — US disclosed
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION 2011-07-28 — — US disclosed
WO-2011075630-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2011-06-23 — — WO disclosed
WO-2011075630-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2011-06-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS PIK3R1, PIK3R3, PIK3R2 L3MBTL1 2960/4885HSD11B1 670/4885PDE4A 2583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.