Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.46 |
| ▸ | TDO2 | P48775 | 5/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HEXA | P06865 | 1/20 | 0.35 |
| ▸ | HEXB | P07686 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27489118 | 0.79 | DPP4 (0.41) | IDO1TDO2ADORA2ASMN1; SMN2DPP4 | |
| SCHEMBL27507080 | 0.75 | DCTPP1 (0.43) | IDO1TDO2KCNN4ADORA2ASMN1; SMN2 | |
| SCHEMBL24833974 | 0.72 | NSD2 (0.46) | IDO1TDO2SMN1; SMN2DPP4CYP2D6 | |
| SCHEMBL5599467 | 0.70 | CSNK2A2 (0.49) | IDO1KCNN4DHFRSMN1; SMN2CYP2D6 | |
| SCHEMBL23422767 | 0.67 | TDO2 (0.46) | IDO1TDO2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL1132663 | 0.67 | MYC (0.50) | DHFRCYP2D6HEXAHEXBMAPK1 | |
| SCHEMBL22134296 | 0.66 | ALDH1A1 (0.42) | CYP2D6MAPT | |
| SCHEMBL12324828 | 0.66 | IDO1 (0.42) | IDO1TDO2KCNN4SMN1; SMN2DPP4 | |
| SCHEMBL14551981 | 0.66 | IDO1 (0.42) | IDO1TDO2KCNN4SMN1; SMN2DPP4 | |
| SCHEMBL25015339 | 0.66 | TTR (0.46) | MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089373-A9 | STEROIDS AND PROTEIN-CONJUGATES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018089373-A2 | STEROIDS AND PROTEIN-CONJUGATES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |