Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20223486 | 0.79 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL777155 | 0.78 | ALDH1A1 (0.39) | ALDH1A1MAPTTDP1 | |
| SCHEMBL13461896 | 0.77 | NFE2L2 (0.35) | TDP1CYP3A4 | |
| SCHEMBL11855535 | 0.75 | — | — | |
| SCHEMBL904138 | 0.75 | DGAT1 (0.37) | ALDH1A1LMNA | |
| SCHEMBL30142219 | 0.75 | CYP3A4 (0.48) | ALDH1A1CASP1MAPTTDP1CYP3A4 | |
| SCHEMBL6815115 | 0.75 | CYP3A4 (0.48) | ALDH1A1CASP1MAPTTDP1CYP3A4 | |
| SCHEMBL23609215 | 0.75 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL22854124 | 0.73 | PRKCI (0.39) | ALDH1A1CASP1MAPTMAPK1GFER | |
| SCHEMBL7860592 | 0.73 | CYP3A4 (0.47) | ALDH1A1CASP1MAPTTDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261294-A1 | NOVEL APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | MANKIND PHARMA LTD. (IN) | 2020-12-30 | — | — | WO | disclosed |
| WO-2018089373-A9 | STEROIDS AND PROTEIN-CONJUGATES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018089373-A2 | STEROIDS AND PROTEIN-CONJUGATES THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |