Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20225778 | 0.81 | CYP19A1 (0.37) | MAPTCYP2C9LMNAHPGDSMN1; SMN2 | |
| SCHEMBL20150211 | 0.75 | THRB (0.39) | THRBMAPTCYP2C9VCAM1LMNA | |
| SCHEMBL20150212 | 0.69 | ERN1 (0.45) | THRBMAPTVCAM1LMNAPOLB | |
| SCHEMBL20150268 | 0.68 | LMNA (0.40) | THRBMAPTVCAM1LMNAPOLB | |
| SCHEMBL30908542 | 0.67 | TSHR (0.60) | THRBVCAM1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15703077 | 0.67 | TSHR (0.60) | THRBVCAM1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20150214 | 0.67 | TYK2 (0.43) | THRBMAPTCYP2C9VCAM1POLB | |
| SCHEMBL17785771 | 0.66 | VCAM1 (0.44) | THRBVCAM1POLBMEN1KMT2A | |
| SCHEMBL11879430 | 0.66 | VCAM1 (0.48) | THRBMAPTVCAM1LMNAHPGD | |
| SCHEMBL11878819 | 0.66 | TSHR (0.56) | THRBMAPTVCAM1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | THRB 758/4885MAPT 1236/4885CYP2C9 4115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.