552-02 Free Base

552-02 Free Base

SCHEMBL2015164

NC(=NCCCCc1ccc(OCC(O)CO)cc1)NC(=O)c1nc(Cl)c(N)nc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SCNN1A P37088 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL916348 0.97 SCNN1A (0.94) SCNN1A
Hydrochloric Acid SCHEMBL937636 0.89 SCNN1A (0.79) SCNN1A
SCHEMBL938374 0.86 SCNN1A (0.75) SCNN1A
SCHEMBL5671579 0.86 SCNN1A (0.86) SCNN1A
SCHEMBL15092805 0.86 SCNN1A (0.75) SCNN1A
SCHEMBL1996614 0.86 SCNN1A (0.75) SCNN1A
552-02 Free Base SCHEMBL9913774 0.83 SCNN1A (0.71) SCNN1A
552-02 Free Base SCHEMBL9913757 0.83 SCNN1A (0.71) SCNN1A
552-02 Free Base SCHEMBL2015162 0.83 SCNN1A (0.71) SCNN1A
SCHEMBL19361273 0.82 SCNN1A (0.69) SCNN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332151-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMA (US) 2025-10-30 US claimed
CN-119947720-A Methods of treating cystic fibrosis 弗特克斯药品有限公司 2025-05-06 CN claimed
EP-4525858-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS Vertex Pharmaceuticals Incorporated (US) 2025-03-26 EP claimed
WO-2023224931-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-11-23 WO claimed
EP-4247817-A1 MACROCYCLES CONTAINING A 1,3,4-OXADIAZOLE RING FOR USE AS MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2023-09-27 EP claimed
CN-116670140-A Macrocyclic compounds containing 1,3, 4-oxadiazole rings as modulators of cystic fibrosis transmembrane conductance regulator 弗特克斯药品有限公司 2023-08-29 CN claimed
US-20230099745-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) 2023-03-30 US claimed
CN-113956648-B High-strength silicate/polyurethane urea-based composite reinforcing material and preparation method thereof 山西凝固力新型材料股份有限公司 2023-02-03 CN claimed
WO-2022109573-A1 MACROCYCLES CONTAINING A 1,3,4-OXADIAZOLE RING FOR USE AS MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-05-27 WO claimed
CN-109475552-B Methods and compositions for appetite control and weight management 上海药苑生物科技有限公司 2022-04-05 CN claimed
CN-113956648-A High-strength silicate/polyurethane urea-based composite reinforcing material and preparation method thereof 山西凝固力新型材料股份有限公司 2022-01-21 CN claimed
US-20250332151-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMA (US) 2025-10-30 US disclosed
US-20250221971-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS VERTEX PHARMA (US) 2025-07-10 US disclosed
US-12324802-B2 Modulators of cystic fibrosis transmembrane conductance regulator VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-06-10 US disclosed
US-20250179091-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2025-06-05 US disclosed
EP-3183021-A1 FLUID RESERVOIR FOR AN AEROSOL GENERATOR AND AEROSOL GENERATOR COMPRISING THE FLUID RESERVOIR PARI Pharma GmbH (DE) 2017-06-28 EP disclosed
EP-3127616-A1 METHOD OF MANUFACTURING A VIBRATABLE HEAD FOR AN AEROSOL GENERATOR AND VIBRATABLE HEAD FOR AN AEROSOL GENERATOR PARI Pharma GmbH (DE) 2017-02-08 EP disclosed
WO-2016026802-A1 FLUID RESERVOIR FOR AN AEROSOL GENERATOR AND AEROSOL GENERATOR COMPRISING THE FLUID RESERVOIR PARI PHARMA GMBH (DE) 2016-02-25 WO disclosed
EP-2194966-B1 AEROSOLS FOR SINUNASAL DRUG DELIVERY PARI PHARMA GMBH (DE) 2015-12-02 EP disclosed
WO-2011073662-A1 COMBINATION OF A BENZOXAZINONE AND A FURTHER AGENT FOR TREATING RESPIRATORY DISEASES ASTRAZENECA AB (SE) 2011-06-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250221971-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS CFTR, SLC26A4, SLC26A3 SCNN1A 11/4885
US-20250332151-A1 METHODS OF TREATMENT FOR CYSTIC FIBROSIS CFTR, SLC26A4, SLC26A3 SCNN1A 12/4885
US-20250179091-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B SCNN1A 5/4885
US-12324802-B2 Modulators of cystic fibrosis transmembrane conductance regulator CFTR, SCNN1G, SCNN1B SCNN1A 5/4885
US-20230099745-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B SCNN1A 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.