Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015741 | 0.89 | L3MBTL1 (0.44) | CDK1KDM4EL3MBTL1CCR1CCR8 | |
| SCHEMBL2017973 | 0.82 | L3MBTL1 (0.43) | CDK1KDM4EL3MBTL1CCR1CCR8 | |
| SCHEMBL2010932 | 0.77 | KDM4E (0.43) | KDM4EL3MBTL1CCR1CCR8LMNA | |
| SCHEMBL2017970 | 0.76 | KDM4E (0.44) | KDM4EL3MBTL1CCR1CCR8LMNA | |
| SCHEMBL2015201 | 0.76 | L3MBTL1 (0.46) | KDM4EL3MBTL1CCR1CCR8LMNA | |
| SCHEMBL2011286 | 0.75 | PIK3CD (0.40) | KDM4EL3MBTL1CCR1CCR8LMNA | |
| SCHEMBL8345105 | 0.74 | KDM4E (0.60) | CDK1KDM4EL3MBTL1CCR1CCR8 | |
| SCHEMBL2015740 | 0.73 | L3MBTL1 (0.43) | KDM4EL3MBTL1CCR1CCR8LMNA | |
| SCHEMBL2320450 | 0.71 | KDM4E (0.57) | CDK1KDM4EL3MBTL1CCR1CCR8 | |
| SCHEMBL2015779 | 0.70 | PIK3CD (0.44) | CDK1KDM4EL3MBTL1CCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |