Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10193818 | 0.82 | HDAC1 (0.36) | HDAC1HDAC3HDAC2ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7292521 | 0.78 | HDAC3 (0.38) | HDAC1HDAC3HDAC2ADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL9871265 | 0.78 | HDAC3 (0.38) | HDAC1HDAC3HDAC2ADRA2AADRA2B | |
| SCHEMBL12805682 | 0.78 | PAM (0.55) | ALDH1A1HDAC1HDAC3HDAC2PADI4 | |
| SCHEMBL17787989 | 0.78 | HDAC1 (0.46) | ALDH1A1HDAC1HDAC3HDAC2PADI4 | |
| SCHEMBL12074867 | 0.78 | PAM (0.55) | ALDH1A1HDAC1HDAC3HDAC2PADI4 | |
| SCHEMBL6559246 | 0.77 | HDAC3 (0.39) | HDAC1HDAC3HDAC2ADRA2AADRA2B | |
| SCHEMBL4303773 | 0.77 | APLNR (0.43) | ALDH1A1CYP3A4HDAC1ADRA2AADRA2B | |
| SCHEMBL5253130 | 0.77 | ALDH1A1 (0.41) | ALDH1A1CYP3A4RECQLRHOAPADI4 | |
| SCHEMBL5253126 | 0.77 | ALDH1A1 (0.41) | ALDH1A1CYP3A4RECQLRHOAPADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134665-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134665-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | MAP3K19, MAP3K20, MAP3K1 | ALDH1A1 1542/4885CYP3A4 2069/4885RECQL 1407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.