Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12074867 | 1.00 | PAM (0.55) | PAMHDAC1HDAC3HDAC2TSHR | |
| SCHEMBL17787989 | 0.86 | HDAC1 (0.46) | PAMHDAC1HDAC3HDAC2TSHR | |
| SCHEMBL23992172 | 0.85 | HDAC1 (0.47) | PAMHDAC1HDAC3HDAC2TSHR | |
| SCHEMBL12074865 | 0.80 | PAM (0.51) | PAMHDAC1HDAC3HDAC2SMN1; SMN2 | |
| SCHEMBL22295563 | 0.79 | PAM (0.55) | PAMSMN1; SMN2P4HTMTBXAS1ALDH1A1 | |
| SCHEMBL12074871 | 0.79 | PAM (0.50) | PAMHDAC1HDAC3HDAC2SMN1; SMN2 | |
| SCHEMBL1124258 | 0.79 | P4HTM (0.64) | HDAC1HDAC3HDAC2TSHRSMN1; SMN2 | |
| SCHEMBL1124260 | 0.79 | P4HTM (0.64) | HDAC1HDAC3HDAC2TSHRSMN1; SMN2 | |
| SCHEMBL20152895 | 0.78 | ALDH1A1 (0.46) | HDAC1HDAC3HDAC2PADI4HDAC6 | |
| SCHEMBL9044098 | 0.78 | PAM (0.68) | PAMSMN1; SMN2PDE5AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252810-A1 | FATTY ACID NON-FLUSHING NIACIN DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. (US) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252810-A1 | FATTY ACID NON-FLUSHING NIACIN DERIVATIVES AND THEIR USES | NAMPT, FASN, FFAR2 | PAM 1937/4885HDAC1 1810/4885HDAC3 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.